Mescaline is the extract of a spineless cactus known as peyote, and it can also be produced synthetically (in a lab). It’s a type of drug known as a hallucinogen or psychedelic. While peyote has been used ceremonially for thousands of years by indigenous cultures such as the Navajo, mescaline is also a recreational drug that may be abused, possibly leading to tolerance and dependence. Outside of ceremonial use by the Native American Church, mescaline is illegal in the United States. Symptoms of mescaline withdrawal may occur in someone who takes the drug often.

What Are the Mescaline Withdrawal Symptoms?

Mescaline is not physically addictive like some other substances, such as heroin and meth, but sometimes it can cause a psychological addiction. It can also cause very unpleasant side effects. These side effects may include restlessness, depression, and memory problems. Other mescaline side effects may include nausea, vomiting, high blood pressure, and dizziness, among others.

Like most other drugs, the more someone uses it, they build up a tolerance and have to take more to get the same effect. When they do stop taking mescaline, they will most likely experience withdrawal symptoms such as a dip in serotonin, a neurotransmitter that helps with mood. This dip in serotonin can lead to a state called dysphoria. Dysphoria means the person experiences a feeling of depression and dissatisfaction. They may also feel anxious and restless.

What Are the Stages of the Mescaline Withdrawal Timeline?

Soon after someone stops taking mescaline, they may feel a drop in their mood. They may feel depressed, anxious, and unhappy.

A couple of serious long-term health effects can also result from chronic use of mescaline and other psychedelic drugs:

  1. Hallucinogen-Persisting Perception Disorder (HPDD), also known as “flashbacks.” Flashbacks often occur without warning and may include hallucinations and visual disturbances.
  2. Persistent or drug-induced psychosis, which causes visual disturbances, disorganized thinking, paranoia, and mood changes.

Why Should I Detox?

Quitting drugs cold turkey may sound like a good idea, but it can be difficult, painful, and dangerous. In some cases, it can be dangerous and even deadly.

Given the difficult physical symptoms, withdrawing on your own without professional medical help can be very challenging. It’s important to find a professional, medically assisted detox program to support you during the process of Mescaline withdrawal.

Doing this will ensure that you are carefully monitored in a safe environment while your body goes through the difficult detoxification process. Participating in an addiction treatment program also gives you a better chance at lasting recovery as a result of the structured medical and emotional support you will receive.

What is the Next Treatment Step?

A full continuum of treatment ensures the best opportunity for a successful recovery. Following a full continuum of treatment means starting with the medical detox process and then progressing gradually from an inpatient status to outpatient treatment. You will then have the opportunity to participate in an alumni program after the formal treatment program is completed. The stages of addiction treatment include:


The primary goal is medical stabilization during the first stage of withdrawal treatment, which is known as detox. Expect


the detox stage to last from a few days up to a week. When you arrive, your medical team—which will include doctors, nurses, and support staff— will complete your comprehensive medical assessment, which will help determine your level

of addiction and additional medical needs you may have. The assessment includes a medical exam plus a urine screening for drugs.

Your medical team will monitor you 24/7 to help manage uncomfortable withdrawal symptoms and prevent dangerous

Mescaline withdrawal symptoms.

Many people also experience anxiety, depression, and other emotional and psychological challenges during the detox period. Your treatment plan will also include comprehensive support to help you with these symptoms. A longer-term treatment plan will be put into place for you once you are medically stabilized.

Partial Hospitalization

Partial hospitalization (PHP) is in-between outpatient treatment and inpatient care. The goal of PHP is to stabilize your mental status and better prepare you for success once you return to independent living after you leave the treatment center. During this stage, you’ll live at a transitional living facility while undergoing a supportive and rigorous treatment program. This program will be five days a week for six hours each day. You will be able to participate in individual, group, and family therapy programs to help you address emotional and mental health needs.

Learning positive life skills, coping mechanisms, and techniques to help prevent relapse so that you will be prepared for long-term recovery will be the primary focus during PHP.

Intensive Outpatient

The next stage is the intensive outpatient program (IOP). An IOP allows you to live at home while also attending counseling and programs to help support your recovery. Depending on your treatment plan, you will participate in about nine or more hours of clinical therapy several times each week.

Intensive outpatient therapy will help you to continue learning new ways to manage cravings, stress, and other challenging issues that may arise once you live on your own again. After you complete the IOP stage, you will transition into the Outpatient and Alumni programs, which is also known as aftercare.


You will have the opportunity to meet other treatment center alumni during weekly support groups and social events after you complete the formal treatment program. These aftercare opportunities spent with other alumni members can help you develop new friendships and build social support with others who understand the recovery process.

Being a part of this supportive network can help you grow while focusing on your recovery and adjusting to life after the treatment program. It can also be a safe space to share relapse prevention strategies, new experiences, and techniques for stress management. Most of all, it can be a way to enjoy time with new friends.

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