In 2017, the U.S. Food and Drug Administration (FDA) began issuing warnings about kratom, and it now identifies 44 deaths related to its use. In a majority of the cases, however, most kratom associated deaths were said to have been the result of adulterated products (drugs mixed in with kratom). All cases, however, were due to mixing kratom with other potent substances such as opioids, benzodiazepines, alcohol, gabapentin, and cough syrup. While kratom has been labeled as an opioid and confirmed in many deaths, how does it interact with other drugs like Adderall?

What Is Kratom?

Kratom is produced from a tropical tree known as Mitragyna speciosa, which is native to Southeast Asia. The leaves contain compounds that can have psychotropic or mind-altering effects. Kratom is currently a legal substance in the United States although some states and cities have banned it. Kratom, which also goes by names such as Biak, Ketum, Kakuam, Ithang, and Thom, can be purchased online or at smoke shops.

Kratom is most commonly consumed in a pill, capsule, or extract, but some chew the leaves or brew the dried powdered leaves as a tea. Kratom can produce effects similar to stimulants, and effects similar to opioids. In fact, the FDA recently considered kratom an opiate, but more research is necessary to understand how it can produce stimulating yet sedative effects depending on dose.

What Is Adderall?

Bottle of Adderall capsules spilled

Adderall is a central nervous system (CNS) stimulant that can only be obtained with a doctor’s prescription. The Schedule II drug is used in the treatment of attention-deficit/hyperactivity disorder (ADHD), and narcolepsy. Its effects are similar to those of methamphetamine, and those who use the drug over time could develop an addiction. That is not to say all who use it will become addicted, but there is a likelihood of the event to occur.

Adderall is a beneficial drug for therapeutic use. Adderall works by elevating the levels of catecholamines in the synaptic spaces. Once the enzyme is activated, the neurotransmitter shows more prolonged action. Adderall also enhances the release of dopamine. This leads to increased alertness, decreased fatigue, depressed appetite, and insomnia. Higher doses of the drug, however, can cause psychosis that can lead to convulsions. High doses of the drug can lead to psychosis and result in outcomes that are sometimes fatal. So the question remains, can you mix kratom and Adderall safely?

How Does Adderall and Kratom Combination Work?

Kratom and Adderall work in synergy, and at low doses, they both act as stimulants. Adderall produces a sense of energy and enhances productivity. Kratom has more calming effects that are relaxing, which is why it is classified as an opioid. Separately, both drugs create a sense of euphoria, but when used together, they can give the user a feeling of contentment. At higher doses, though, there is a variation in the behavior of both drugs. Kratom will produce a sedative effect that can make one sleepy while Adderall can cause insomnia and a more energetic impact.

Users of the drug(s) have mentioned that, because Adderall produces effects that disturb their sleep, using kratom at the end of their high will help them to induce sleep. Others, however, note that since kratom is also a stimulant drug, it will potentiate the effects of Adderall. Kratom has helped many individuals combat the crash that Adderall can provide, and it has been said that the combination only works when you find the right strain of kratom.

Using the drugs together can induce euphoria as well as sharpen one’s focus. Kratom helps provide its user with an elevated mood and also inhibits the user from feeling depression that is a side effect of Adderall. Another benefit of kratom is that is can help to manage pain because of the skeletal muscle contraction. It also gives the person using the drugs confidence and negates the effects of a comedown, but is it actually safe?

Adderall Side Effects

Although Adderall is commonly prescribed, there still are adverse side effects that can occur from use. You must speak to a doctor before taking the drug. Some common Adderall side effects include:

  • Dizziness
  • Nervousness
  • Headache
  • Stomach ache
  • Restlessness
  • Decreased appetite
  • Dry mouth
  • Weight loss
  • Insomnia
  • Diarrhea
  • Loss of interest in sex

More serious side effects include:

  • Seizures
  • Vision changes
  • Trouble breathing
  • Chest pain
  • Fainting
  • Hallucinations
  • Delusions
  • Severe skin rash
  • Irregular heartbeat

If you experience any of the above-listed effects, you must immediately call your primary care physician or go to the hospital.

Kratom Side Effects

Users describe kratom’s effects to be felt soon after ingestion, and the effects can last anywhere from two to five hours. Side effects of kratom include:

  • Itching
  • Nausea
  • Constipation
  • Dry mouth
  • Increased urination
  • Appetite loss
  • Hallucinations
  • Seizures
  • Liver damage

Long-term side effects of kratom include:

  • Weight loss
  • Fatigue
  • Dark spots
  • Psychosis

If you experience adverse side effects as mentioned above, you must contact your healthcare provider to discuss treatment options.

Is Adderall and Kratom Safe?

While some users have reported that the combination of Adderall and kratom are satisfying and not dangerous, that is not the case. Over the past several years, more cases of deaths attributed to kratom have been taking place. The DEA is waiting for more information about the drug so that it can once and for all make it illegal. There are a few critical factors to take into consideration when weighing if the combination is safe. Just because some users report positive experiences, everyone is different in how they process drugs in their system. Where one person has an uplifting high, another could be poisoned and overdose.

One-hundred percent of all cases where kratom caused death other substances were present in the person’s system. At high doses, kratom has been linked to imitate more powerful drugs like morphine, and the combination can cause severe health risks. Kratom use has been associated with hepatotoxicity, stomach ulcers, and elevated liver enzymes. There are even reports of kratom causing jaundice. What does this say about Adderall and kratom mixture?

Because of the adverse side effects presented by both drugs individually, it would be in users’ best interest to stay away from using both drugs. Long-term Adderall use can cause problems on its own, and mixing it with a drug like kratom can cause permanent effects in which there is no cure.

To date, there is still not enough research to adequately describe the true dangers of mixing the drugs, but due to all deaths attributed to kratom having other substances present, it would be in your best interest to avoid mixing Adderall and kratom. Maybe it can be done safely, but with a lack of research about its effects, it’s not worth experimenting.

If you have been experimenting with the drugs and think you may be developing a chemical dependency, it’s important to get help.

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